Endocrine Abstracts

Prediction of the biological behavior in non-functioning pituitary adenomas (NFPA) according to morphological criteria is highly inaccurate. Reliable prognostic molecular markers could be useful in providing guidance in NFPA post-surgical follow-up.Aim: To identify differentially expressed genes between aggressive and non-aggressive NFPAs and to assess their prognostic value.Methods: Samples analyzed were selected from a series of ...

Although we know the gene alterations associated with KAL 2, at present we still do not know certain mutations of the fibroblast factor receptor 1 gene (FGFR gene) that even show complete penetrance of the syndrome. Kallman syndrome is a genetic disease of embryonic development characterized by the association of hypogonadotropic hypogonadism due to GnRH hormone deficiency because of agenesis or hypoplasia of the olfactory sulci. Three subtypes have been described; the classic...

Objectives: To describe modifiable sociodemographic and clinical risk factors predictive of severe hypoglycemia with need for urgent health care in adults with type 1 diabetes (T1DM).Methods: Multicenter, observational and retrospective study with case-control design.Cases: T1DM adults with severe hypoglycemia, defined as glycemia <70 mg/dl requiring urgent out-of-hospital health care for its resolution. Data source, geographic...